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ТОМ 21, СТ. 47 (стр. 579-592)   |   21 мая 2020 г.   

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Клиническая медицина » Терапия » Клиническая токсикология

Анализ современных методов и средств экспрессной индикации растительных токсинов, ингибирующих синтез белка

Митева О. А., Быкова К. А., Мясникова И. А., Чепур С. В., Аль-Шехадат Р. И.

Государственный научно-исследовательский испытательный институт военной медицины Министерства обороны Российской Федерации

Резюме

В статье приведeн обзор современных подходов, методов и средств экспресс-индикации одной из наиболее значимых групп токсинов, ингибирующих синтез белка, определяющий перспективу разработки и внедрения на рынок как отечественных тест-систем, так и платформ автоматического анализа для выявления этих токсинов в объектах окружающей среды и биологическом материале.


Ключевые слова

биобезопасность, рибосом-инактивирующие белки, лектины, детекция и идентификация.

Список литературы

1. Измерение концентраций вредных веществ в воздухе рабочей зоны: Сб. метод, указаний МУК 4.1.100-96-МУК 4.1.197-96. // Официальное издание, М.: Информационно-издательский центр Минздрава России. - 1998. - Вып. 29. - 429 с.


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3. Челнокова О.B. Конформационные изменения растительных токсинов в ходе внутриклеточного транспорта // Дис.... канд. биол. наук. - М., 2004. - 122 с.


4. Armstrong S., Yates S. P., Merrill A. R. Insight into the Catalytic Mechanism of Pseudomonas aeruginosa Exotoxin A studies of toxin interaction with eukaryotic elongation factor-2 // Journal of Biological Chemistry. - 2002. - Т. 277. - 48. - Р. 46669-46675.


5. Bozza W. P. et al. Ricin detection: Tracking active toxin // Biotechnology advances. - 2015. - Т. 33. - 1. - Р. 117-123.


6. Cloney L. P. et al. RAMP?: High Accuracy from Immunochromatographic Assays by the Use of Internal Control Ratios // Clinical Chemistry. - 2003. - Т. 49. - 10. - Р. 1775-1777.


7. Darby S. M., Miller M. L., Allen R. O. Forensic determination of ricin and the alkaloid marker ricinine from castor bean extracts // Journal of Forensic Science. - 2001. - Т. 46. - 5. - Р. 1033-1042.


8. Delehanty J. B., Ligler F. S. A microarray immunoassay for simultaneous detection of proteins and bacteria // Analytical Chemistry. - 2002. - Т. 74. - 21. - Р. 5681-5687.


9. Fulton R. E., Thompson H. G. Fluorogenic Hand‐Held Immunoassay for the Identification of Ricin: Rapid Analyte Measurement Platform // Journal of immunoassay & immunochemistry. - 2007. - Т. 28. - 3. - Р. 227-241.


10. Gao S. et al. Colloidal Gold-Based Immunochromatographic Test Strip for Rapid Detection of Abrin in Food Samples // Journal of food protection. - 2012. - Т. 75. - 1. - Р. 112-117.


11. Garber E. A. E. Toxicity and detection of ricin and abrin in beverages // Journal of food protection. - 2008. - Т. 71. - 9. - Р. 1875-1883.


12. Garber E. A. E., Venkateswaran K. V., OBrien T. W. Simultaneous multiplex detection and confirmation of the proteinaceous toxins abrin, ricin, botulinum toxins, and Staphylococcus enterotoxins A, B, and C in food // Journal of agricultural and food chemistry. - 2010. - Т. 58. - 11. - Р. 6600-6607.


13. Garber E. A. E., Walker J. L., O'BRIEN T. W. Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies // Journal of food protection. - 2008. - Т. 71. - 9. - Р. 1868-1874.


14. Garber E.A.E., Thole J. Application of Microwave Irradiation and Heat to Improve Gliadin Detection and Ricin ELISA Throughput with Food Samples // Toxins. 2015. - Vol. 7. - 6. - P. 2135-2144.


15. Girbés T. et al. Description, distribution, activity and phylogenetic relationship of ribosome-inactivating proteins in plants, fungi and bacteria // Mini reviews in medicinal chemistry. - 2004. - Т. 4. - 5. - Р. 461-476.


16. Griffiths G. D., Newman H. V., Gee D. J. Immunocytochemical detection of ricin. II. Further studies using the immunoperoxidase method //The Histochemical Journal. - 1986. - Т. 18. - 4. - Р. 189-195.


17. He X. et al. Detection of abrin holotoxin using novel monoclonal antibodies //Toxins. - 2017. - Т. 9. - 12. - Р. 386.


18. Johnson R. C. et al. Quantification of ricinine in rat and human urine: a biomarker for ricin exposure //Journal of analytical toxicology. - 2005. - Т. 29. - 3. - Р. 149-155.


19. Leith A. G., Griffiths G. D., Green M. A. Quantification of ricin toxin using a highly sensitive avidin/biotin enzyme-linked immunosorbent assay //Journal of the Forensic Science Society. - 1988. - Т. 28. - 4. - Р. 227-236.


20. Pauly D. et al. Monitoring of laying capacity, immunoglobulin Y concentration, and antibody titer development in chickens immunized with ricin and botulinum toxins over a two-year period // Poult. Sci. - 2009. - Vol. 88. - 2. - P. 281-290.


21. Pauly D. et al. Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay // The Analyst. - 2009. - Vol. 134. - 10. - P. 2028-2039.


22. Poli M. A. et al. Detection of ricin by colorimetric and chemiluminescence ELISA // Toxicon. - 1994. - Т. 32. - 11. - Р. 1371-1377.


23. Ramage J. G. et al. Comprehensive laboratory evaluation of a specific lateral flow assay for the presumptive identification of abrin in suspicious white powders and environmental samples // Biosecurity and bioterrorism: biodefense strategy, practice, and science. - 2014. - Т. 12. - 1. - Р. 49-62.


24. Shyu H. F. et al. Monoclonal antibody-based enzyme immunoassay for detection of ricin // Hybridoma and hybridomics. - 2002. - Т. 21. - 1. - Р. 69-73.


25. Simon S. et al. Recommended Immunological Assays to Screen for Ricin-Containing Samples // Toxins. - 2015. - Vol. 7. - 12. - P. 4967-4986.


26. Simonova M. A. et al. Development of xMAP assay for detection of six protein toxins // Analytical chemistry. - 2012. - Т. 84. - 15. - Р. 6326-6330.


27. Validation of an Antigen-Capture Enzyme-Linked Immunosorbent Assay (ELISA) for the Detection and Quantification of Ricin Toxin // PloS One. - 2011. - Vol. 6. - 5. - P. 201-266.


28. Wadkins R. M. et al. Detection of multiple toxic agents using a planar array immunosensor // Biosensors and Bioelectronics. - 1998. - Т. 13. - 3-4. - Р. 407-415.


29. Weingart O. G. et al. A bioanalytical platform for simultaneous detection and quantification of biological toxins // Sensors. - 2012. - Т. 12. - 2. - Р. 2324-2339.


30. Zhou Y. et al. An enhanced ELISA based on modified colloidal gold nanoparticles for the detection of Pb (II) // Biosensors and Bioelectronics. - 2011. - Т. 26. - 8. - Р. 3700-3704.





Reference


1. Measurement of concentrations of harmful substances in the air of the working area: collection of guidelines MUK 4.1.100-96-MUK 4.1.197-96. // Official publication, M .: Information and Publishing Center of the Ministry of Health of Russia.- 1998. - N 29. - 429 p. method of guidance. [In Russian].


2. Spitsyn A. N., Osina N.A., Germanchuk V. G., Utkin D. V., Sharova I. N., Kuklev V. E., Portenko S. A.. Nonspecific indication of microorganisms in environmental objects // Problemy Osobo Opasnykh Infektsii. - 2018. - N 1. - P. 66-70. [In Russian].


3. Chelnokova O.B. Conformational changes in plant toxins during intracellular transport // Dis. kand. biol. nauk. - M., 2004. - 122 p. [In Russian].


4. Armstrong S., Yates S. P., Merrill A. R. Insight into the Catalytic Mechanism of Pseudomonas aeruginosa Exotoxin A studies of toxin interaction with eukaryotic elongation factor-2 // Journal of Biological Chemistry. - 2002. - Т. 277. - 48. - Р. 46669-46675.


5. Bozza W. P. et al. Ricin detection: Tracking active toxin // Biotechnology advances. - 2015. - Т. 33. - 1. - Р. 117-123.


6. Cloney L. P. et al. RAMP: High Accuracy from Immunochromatographic Assays by the Use of Internal Control Ratios // Clinical Chemistry. - 2003. - Т. 49. - 10. - Р. 1775-1777.


7. Darby S. M., Miller M. L., Allen R. O. Forensic determination of ricin and the alkaloid marker ricinine from castor bean extracts // Journal of Forensic Science. - 2001. - Т. 46. - 5. - Р. 1033-1042.


8. Delehanty J. B., Ligler F. S. A microarray immunoassay for simultaneous detection of proteins and bacteria // Analytical Chemistry. - 2002. - Т. 74. - 21. - Р. 5681-5687.


9. Fulton R. E., Thompson H. G. Fluorogenic Hand‐Held Immunoassay for the Identification of Ricin: Rapid Analyte Measurement Platform // Journal of immunoassay & immunochemistry. - 2007. - Т. 28. - 3. - Р. 227-241.


10. Gao S. et al. Colloidal Gold-Based Immunochromatographic Test Strip for Rapid Detection of Abrin in Food Samples // Journal of food protection. - 2012. - Т. 75. - 1. - Р. 112-117.


11. Garber E. A. E. Toxicity and detection of ricin and abrin in beverages // Journal of food protection. - 2008. - Т. 71. - 9. - Р. 1875-1883.


12. Garber E. A. E., Venkateswaran K. V., OBrien T. W. Simultaneous multiplex detection and confirmation of the proteinaceous toxins abrin, ricin, botulinum toxins, and Staphylococcus enterotoxins A, B, and C in food // Journal of agricultural and food chemistry. - 2010. - Т. 58. - 11. - Р. 6600-6607.


13. Garber E. A. E., Walker J. L., O'BRIEN T. W. Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies // Journal of food protection. - 2008. - Т. 71. - 9. - Р. 1868-1874.


14. Garber E.A.E., Thole J. Application of Microwave Irradiation and Heat to Improve Gliadin Detection and Ricin ELISA Throughput with Food Samples // Toxins. 2015. - Vol. 7. - 6. - P. 2135-2144.


15. Girbés T. et al. Description, distribution, activity and phylogenetic relationship of ribosome-inactivating proteins in plants, fungi and bacteria // Mini reviews in medicinal chemistry. - 2004. - Т. 4. - 5. - Р. 461-476.


16. Griffiths G. D., Newman H. V., Gee D. J. Immunocytochemical detection of ricin. II. Further studies using the immunoperoxidase method //The Histochemical Journal. - 1986. - Т. 18. - 4. - Р. 189-195.


17. He X. et al. Detection of abrin holotoxin using novel monoclonal antibodies //Toxins. - 2017. - Т. 9. - 12. - Р. 386.


18. Johnson R. C. et al. Quantification of ricinine in rat and human urine: a biomarker for ricin exposure //Journal of analytical toxicology. - 2005. - Т. 29. - 3. - Р. 149-155.


19. Leith A. G., Griffiths G. D., Green M. A. Quantification of ricin toxin using a highly sensitive avidin/biotin enzyme-linked immunosorbent assay //Journal of the Forensic Science Society. - 1988. - Т. 28. - 4. - Р. 227-236.


20. Pauly D. et al. Monitoring of laying capacity, immunoglobulin Y concentration, and antibody titer development in chickens immunized with ricin and botulinum toxins over a two-year period // Poult. Sci. - 2009. - Vol. 88. - 2. - P. 281-290.


21. Pauly D. et al. Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay // The Analyst. - 2009. - Vol. 134. - 10. - P. 2028-2039.


22. Poli M. A. et al. Detection of ricin by colorimetric and chemiluminescence ELISA // Toxicon. - 1994. - Т. 32. - 11. - Р. 1371-1377.


23. Ramage J. G. et al. Comprehensive laboratory evaluation of a specific lateral flow assay for the presumptive identification of abrin in suspicious white powders and environmental samples // Biosecurity and bioterrorism: biodefense strategy, practice, and science. - 2014. - Т. 12. - 1. - Р. 49-62.


24. Shyu H. F. et al. Monoclonal antibody-based enzyme immunoassay for detection of ricin // Hybridoma and hybridomics. - 2002. - Т. 21. - 1. - Р. 69-73.


25. Simon S. et al. Recommended Immunological Assays to Screen for Ricin-Containing Samples // Toxins. - 2015. - Vol. 7. - 12. - P. 4967-4986.


26. Simonova M. A. et al. Development of xMAP assay for detection of six protein toxins // Analytical chemistry. - 2012. - Т. 84. - 15. - Р. 6326-6330.


27. Validation of an Antigen-Capture Enzyme-Linked Immunosorbent Assay (ELISA) for the Detection and Quantification of Ricin Toxin // PloS One. - 2011. - Vol. 6. - 5. - P. 201-266.


28. Wadkins R. M. et al. Detection of multiple toxic agents using a planar array immunosensor // Biosensors and Bioelectronics. - 1998. - Т. 13. - 3-4. - Р. 407-415


29. Weingart O. G. et al. A bioanalytical platform for simultaneous detection and quantification of biological toxins // Sensors. - 2012. - Т. 12. - 2. - Р. 2324-2339.


30. Zhou Y. et al. An enhanced ELISA based on modified colloidal gold nanoparticles for the detection of Pb (II) // Biosensors and Bioelectronics. - 2011. - Т. 26. - 8. - Р. 3700-3704.

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